Persistent gross lipemia and suspected corneal lipidosis following intravenous lipid therapy in a cat with permethrin toxicosis

• Published in: Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Vol. 26; no. 6; pp. 804 - 808
• Main Authors: Seitz, Marc A., Burkitt-Creedon, Jamie M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2016
• Subjects: Animals; Cat Diseases - diagnosis; Cat Diseases - drug therapy; Cat Diseases - pathology; Cats; Cornea - pathology; corneal opacity; Diagnosis, Differential; Fat Emulsions, Intravenous - adverse effects; Fat Emulsions, Intravenous - therapeutic use; feline; Female; Hyperlipidemias - chemically induced; Hyperlipidemias - diagnosis; Insecticides - poisoning; intralipid; Permethrin - poisoning; Poisoning - diagnosis; Poisoning - veterinary; pyrethroid; toxicity; toxicity; feline; corneal opacity; pyrethroid; intralipid
• ISSN: 1479-3261; 1476-4431
• DOI: 10.1111/vec.12440

Objective To describe the observation of persistent gross lipemia and suspected corneal lipidosis following intravenous lipid therapy (IVLT) in a cat with permethrin toxicosis. Case Summary A 5‐year‐old, spayed female, domestic short‐haired cat with permethrin toxicosis was treated with a high dose of IVLT as an adjunct treatment when it remained severely obtunded following traditional supportive care. The cat received intravenous 20% lipid emulsion as a 1.5 mL/kg bolus given over 10 minutes followed by a constant rate infusion of 0.25 mL/kg/min for 2 hours. The cat developed gross lipemia that persisted at least 48 hours after the single dose of IVLT. Changes consistent with corneal lipidosis were observed and resolved within 1 week after IVLT. New or Unique Information Provided This is the first report documenting the complications of persistent gross lipemia and suspected corneal lipidosis in a cat following IVLT. This report underscores the off‐label, experimental nature of IVLT as a treatment for intoxication in cats.