Plasma and intraprostatic concentrations of ertapenem following preoperative single dose administration: a single-centre prospective experience and clinical implications—the ERTAPRO study

• Published in: International journal of antimicrobial agents Vol. 48; no. 2; pp. 168 - 174
• Main Authors: Dariane, Charles, Amin, Alexandre, Lortholary, Olivier, Lalli, Alexandre, Michel, Constance, Le Guilchet, Thomas, Treluyer, Jean-Marc, Nguyen-Khoa, Thao, De Toma, Claudia, Urien, Saïk, Méjean, Arnaud, Bourget, Philippe, Timsit, Marc-Olivier
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2016
• Subjects: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - analysis; Anti-Bacterial Agents - pharmacokinetics; Antibiotic prophylaxis; Antibiotic Prophylaxis - methods; beta-Lactams - administration & dosage; beta-Lactams - analysis; beta-Lactams - pharmacokinetics; Chromatography; Chromatography, Liquid; Ertapenem; Humans; Infectious Disease; Male; Microbial Sensitivity Tests; Middle Aged; Plasma - chemistry; Preoperative Care - methods; Prostate - chemistry; Prostatic hyperplasia; Tandem Mass Spectrometry; Urinary tract infection; Young Adult; Antibiotic prophylaxis; Prostatic hyperplasia; Urinary tract infection; Ertapenem; Chromatography
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/j.ijantimicag.2016.04.027

Highlights • Ertapenem achieved high prostatic concentrations after a 1 g preoperative injection. • Satisfactory concentrations were achieved 1 h after injection and were maintained even after 12 h. • Prostatic concentrations were above the MIC90 during surgery. • These results match the requirement of a preoperative prophylaxis intervention. • It requires validation on carriers of ESBL-producing bacteria undergoing prostate procedures.