Oxidant/antioxidant status in lambs and sheep with liver and lung cystic echinococcosis diagnosed by ultrasonography and necropsy

• Published in: Veterinary parasitology Vol. 208; no. 3-4; pp. 280 - 285
• Main Authors: Sagkan-Ozturk, A., Durgut, R., Ozturk, O.H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2015
• Subjects: Animals; Antioxidants - metabolism; Cystic echinococcosis (CE); Echinococcosis, Hepatic - diagnostic imaging; Echinococcosis, Hepatic - metabolism; Echinococcosis, Hepatic - parasitology; Echinococcosis, Hepatic - pathology; Echinococcosis, Hepatic - veterinary; Echinococcosis, Pulmonary - diagnostic imaging; Echinococcosis, Pulmonary - metabolism; Echinococcosis, Pulmonary - parasitology; Echinococcosis, Pulmonary - pathology; Echinococcosis, Pulmonary - veterinary; OSI; Oxidants - metabolism; Sheep; Sheep Diseases - diagnostic imaging; Sheep Diseases - metabolism; Sheep Diseases - parasitology; TAC; TOS; Ultrasonography; Cystic echinococcosis (CE); Sheep; TOS; OSI; TAC
• ISSN: 0304-4017; 1873-2550
• DOI: 10.1016/j.vetpar.2014.12.034

•This study first presented TAS, TOS, OSI and serum biochemical profiles in CE.•CE decreased TAC and TOS levels might exceed the generation of free radicals.•The severity of diseases were exhibited by using USG, necropsy and biochemistry.•The study combined the ultrasonography and biochemical profiles for diagnosed of CE.•USG was found useful for diagnosis of CE. The aim of this study was to evaluate total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) in sheep and lambs with cyctic eccinocoocosis (CE) diagnosed by ultrasonography and necropsy findings. A total of 9 sheep and 17 lambs with CE were used in this study and the findings were compared to those of 6 healthy control sheep. Ultrasonography were used for the diagnosis of CE in sheep and lambs, and necropsy was performed to check the presence of cysts in liver and lungs. Serum TOS and TAC were measured by a novel colorimetric method. The TOS-to-TAC ratios were also calculated as OSI values. Serum biochemical profiles were determined by conventional measurement methods as well. The mean values for TOS, TAC and OSI were significantly (p<0.001) lower in sheep and lambs with CE when compared with those of the control sheep, and they were also significantly lower in lambs with CE in comparison to the mean values obtained in sheep with CE. The levels of serum albumin, total cholesterol, creatinine, and triglycerides in lambs with CE were found out to decrease significantly (p<0.001) when compared with those of both sheep with EC and the control group. There were no significant differences between the groups in terms of other serum parameters. In addition, when clinically and some biochemical values were evaluated, CE was found to be more severe in lambs than in sheep. It was concluded that although common diagnostic cyst detection is performed by postmortem examination, ultrasonography could successfully be used in conjunction with serum biochemical profile detection and serum TOS, TAC and OSI measurements for diagnosis of cysts in liver and lungs of severely infected living sheep and lambs. Serum albumin, total cholesterol, creatinine, total protein and triglycerides might be used as indicators in sheep and particularly in lambs for the diagnosis of CE.