THE EFFECT OF PERGOLIDE ON COGNITIVE PERFORMANCE OF YOUNG AND MIDDLE-AGED RATS

In this study, we investigated the effect of pergolide, a dopaminergic agonist, on cognitive ability in young and middle-aged rats using the Morris Water Maze (MWM). Pergolide 0.5/mg/day IP was administered to young and middle-aged rats, whereas only vehicle was given to their age-matched controls....

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Bibliographic Details
Published inInternational journal of neuroscience Vol. 112; no. 9; pp. 1027 - 1036
Main Authors KÜÇÜKATAY, VURAL, BALKAN, SEVIN, YARAS, NAZMI, YARGIÇOGLU, PIRAYE, AGAR, AYSEL
Format Journal Article
LanguageEnglish
Published London Informa UK Ltd 01.09.2002
Taylor & Francis
Subjects
Aging
Aging - physiology
Animals
Behavioral psychophysiology
Biological and medical sciences
Cognition
Cognition - drug effects
Dopamine Agonists - pharmacology
Escape Reaction - drug effects
Fundamental and applied biological sciences. Psychology
Maze Learning - drug effects
Neurotransmission and behavior
Pergolide
Pergolide - pharmacology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Reaction Time - drug effects
Agonist
Rat
Dopamine receptor
Rodentia
Cognition
Vertebrata
Pergolide
Mammalia
Acquisition process
Escape behavior
Animal
Problem solving
Developmental stage
Age
Spatial memory
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Summary:In this study, we investigated the effect of pergolide, a dopaminergic agonist, on cognitive ability in young and middle-aged rats using the Morris Water Maze (MWM). Pergolide 0.5/mg/day IP was administered to young and middle-aged rats, whereas only vehicle was given to their age-matched controls. During the acquisition period of 6 days, young rats showed normal escape latency pattern, which was not affected by pergolide. Middle-aged rats, however, showed poor escape latency pattern, and this poor pattern was also not affected by pergolide. On the 7th day, pergolide decreased retention time of young rats compared to control values. Middle-aged rats also showed reduced retention time. In contrast to the findings of young rats, retention time was not affected by pergolide in middle-aged rats. We concluded that pergolide does not alter escape latency at any age. It has a negative effect on retention time of young rats, whereas it has no effect on middle-aged ones.
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ISSN:0020-7454
1563-5279
1543-5245
DOI:10.1080/00207450290026021