Lipid-based nanocarriers for breast cancer treatment - comprehensive review

• Published in: Drug delivery Vol. 23; no. 4; pp. 1291 - 1305
• Main Authors: Talluri, Siddartha Venkata, Kuppusamy, Gowthamarajan, Karri, Veera Venkata Satyanarayana Reddy, Tummala, Shashank, Madhunapantula, SubbaRao V.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.05.2016
• Subjects: Breast cancer; Breast Neoplasms - chemistry; Breast Neoplasms - drug therapy; Drug Carriers; Female; Humans; lipid; lipid polymer hybrid nanoparticles; Lipids - chemistry; Liposomes; Nanoparticles - chemistry; nanostructured lipid carriers; Nanostructures - chemistry; Nanotechnology; solid lipid nanoparticles; Breast cancer; liposomes; lipid; nanostructured lipid carriers; lipid polymer hybrid nanoparticles; solid lipid nanoparticles
• ISSN: 1071-7544; 1521-0464
• DOI: 10.3109/10717544.2015.1092183

Breast cancer is the second leading cancer-related disease as the most common non-cutaneous malignancy among women. Curative options for breast cancer are limited, therapeutically substantial and associated with toxicities. Emerging nanotechnologies exhibited the possibility to treat or target breast cancer. Among the nanoparticles, various lipid nanoparticles namely, liposomes, solid lipid nanoparticles, nanostructured lipid carriers and lipid polymer hybrid nanoparticles have been developed over the years for the breast cancer therapy and evidences are documented. Concepts are confined in lab scale, which needs to be transferred to large scale to develop active targeting nanomedicine for the clinical utility. So, the present review highlights the recently published studies in the development of lipid-based nanocarriers for breast cancer treatment.