Translocation (5;6) associated with spontaneously remitting congenital leukemia

• Published in: Cancer genetics and cytogenetics Vol. 81; no. 1; pp. 38 - 41
• Main Authors: Mayer, Jennifer L.R., Seashore, Margretta R., Hajjar, Fouad M.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.1995; Elsevier Science
• Subjects: Biological and medical sciences; Bone Marrow - pathology; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 6; Female; Hematologic and hematopoietic diseases; Humans; Infant, Newborn; Karyotyping; Leukemia, Monocytic, Acute - congenital; Leukemia, Monocytic, Acute - genetics; Leukemia, Monocytic, Acute - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Remission, Spontaneous; Translocation, Genetic - genetics; Chromosomal aberration; Human; Monocytic leukemia; Newborn; Acute; Abnormal B5 chromosome; Abnormal chromosome; Remission; Malignant hemopathy; Abnormal C6 chromosome; Chromosome translocation
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/0165-4608(94)00000-X

We describe a newborn with acute monocytic leukemia who underwent spontaneous remission. Chromosomal analysis of this patient's leukemic blasts identified a translocation between 5q31 and 6q21. Chromosome 5 has been implicated in adult leukemogenesis but only rarely in childhood leukemia. Several hematopoietic growth factors and growth factor receptors have been mapped to the long arm of chromosome 5. This report discusses the possible role of these gene products in inducing leukemia in our index case.