Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

• Published in: Journal of receptors and signal transduction Vol. 35; no. 6; p. 600
• Main Authors: Sun, Yu, Liu, Wen-Zhou, Liu, Tao, Feng, Xu, Yang, Nuo, Zhou, Hua-Fu
• Format: Journal Article
• Language: English
• Published: England 02.11.2015
• Subjects: Apoptosis - physiology; Cell Differentiation - physiology; Cell Movement - physiology; Cell Proliferation - physiology; Cellular Senescence - physiology; Extracellular Signal-Regulated MAP Kinases - metabolism; Humans; Mitogen-Activated Protein Kinases - metabolism; Signal Transduction - physiology; Extracellular signal-regulated kinase; signaling pathway; mitogen-activated protein kinases

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (...