Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (...

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Bibliographic Details
Published inJournal of receptors and signal transduction Vol. 35; no. 6; p. 600
Main Authors Sun, Yu, Liu, Wen-Zhou, Liu, Tao, Feng, Xu, Yang, Nuo, Zhou, Hua-Fu
Format Journal Article
LanguageEnglish
Published England 02.11.2015
Subjects
Apoptosis - physiology
Cell Differentiation - physiology
Cell Movement - physiology
Cell Proliferation - physiology
Cellular Senescence - physiology
Extracellular Signal-Regulated MAP Kinases - metabolism
Humans
Mitogen-Activated Protein Kinases - metabolism
Signal Transduction - physiology
Extracellular signal-regulated kinase
signaling pathway
mitogen-activated protein kinases
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Summary:The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.
ISSN:1532-4281
DOI:10.3109/10799893.2015.1030412