Inducible protective processes in animal systems VI. Cross-adaptation and the influence of caffeine on the adaptive response in bone marrow cells of mouse

• Published in: Mutagenesis Vol. 15; no. 3; pp. 271 - 276
• Main Authors: Harish, S.K., Guruprasad, K.P., Mahmood, Riaz, Vasudev, V.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2000
• Subjects: Acclimatization; Animals; Biological and medical sciences; Bone Marrow Cells - cytology; Bone Marrow Cells - drug effects; Caffeine - administration & dosage; Caffeine - pharmacology; Chemical mutagenesis; Chromosome Aberrations; DNA Damage; Ethyl Methanesulfonate - administration & dosage; Ethyl Methanesulfonate - pharmacology; Male; Medical sciences; Mice; Mutagenicity Tests; Mutagens - administration & dosage; Mutagens - pharmacology; Time Factors; Toxicology; Chromosomal aberration; CNS stimulant; Rodentia; Adaptive response; Respiratory analeptic; In vivo; Vertebrata; Mammalia; Cell line; Mouse; Bone marrow; High dose; Adaptation; Caffeine

The effect of caffeine (CAF) (a replicative DNA synthesis inhibitor) given as pre-, inter- and post-treatments on the ethyl methanesulfonate (EMS)-induced adaptive response in in vivo mouse bone marrow cells was studied in order to understand the influence of CAF on the adaptive response. The pre-tr...