Cerebral venous sinus thrombosis in polycythemia vera patients with JAK2V617F mutation

The patient was administered antithrombotic therapy (LMWH, warfarin, and aspirin) and cytoreductive treatment (hydroxyurea and interferon-α [IFN-α]). [...]optic nerve sheath fenestration (ONSF) was performed due to markedly high ICP and visual impairment. Clinical manifestations of CVST are highly v...

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Published inChinese medical journal Vol. 134; no. 10; pp. 1251 - 1253
Main Authors Shen, Hui-Xin, Huang, Xiao-Qin, Fan, Chun-Qiu, Cao, Yan-Xiang, Zhao, Hong, Duan, Jian-Gang
Format Journal Article
LanguageEnglish
Published China Lippincott Williams & Wilkins Ovid Technologies 03.05.2021
Lippincott Williams & Wilkins
Wolters Kluwer
Subjects
Anticoagulants
Aspirin
Biopsy
Blood clots
Bone marrow
Convulsions & seizures
Correspondence
Headaches
Hemoglobin
Humans
Hypertension
Janus Kinase 2 - genetics
Magnetic resonance imaging
Medical imaging
Molecular weight
Mutation
Nausea
Patients
Polycythemia Vera - complications
Polycythemia Vera - genetics
Sinus Thrombosis, Intracranial - diagnostic imaging
Sinus Thrombosis, Intracranial - genetics
Sinuses
Stroke
Thrombocythemia, Essential
Thromboembolism
Thrombosis
Veins & arteries
Visual impairment
Vomiting
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Summary:The patient was administered antithrombotic therapy (LMWH, warfarin, and aspirin) and cytoreductive treatment (hydroxyurea and interferon-α [IFN-α]). [...]optic nerve sheath fenestration (ONSF) was performed due to markedly high ICP and visual impairment. Clinical manifestations of CVST are highly variable,[4] while the clinical course of PV is often indolent, which often leads to missed or delayed diagnosis. [...]the diagnosis of CVST should be considered in idiopathic intracranial hypertension PV patients complaining of a severe unexplained headache or young patients presenting with stroke symptoms or overlapping clinical presentation of these conditions. [...]multiple sinus thrombosis is a frequent occurrence and is confirmed by MRV. [...]ONSF was performed in case 4 for markedly high ICP and visual impairment, where the eyesight improved slowly. Since a previous history of thrombosis has been identified as a risk factor for thromboembolism recurrence; therefore, it is also critical to prevent CVST recurrence.
Bibliography:SourceType-Other Sources-1
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ObjectType-Correspondence-1
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000001484