N -(coumarin-3-yl)cinnamamide Promotes Immunomodulatory, Neuroprotective, and Lung Function-Preserving Effects during Severe Malaria

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 17; no. 1; p. 46
• Main Authors: Gaio, Paulo, Cramer, Allysson, de Melo Oliveira, Natália Fernanda, Porto, Samuel, Kramer, Lucas, Nonato Rabelo, Rayane Aparecida, Pereira, Rafaela das Dores, de Oliveira Santos, Laura Lis, Nascimento Barbosa, César Luís, Silva Oliveira, Fabrício Marcus, Martins Teixeira, Mauro, Castro Russo, Remo, Matos, Maria João, Simão Machado, Fabiana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.12.2023; MDPI
• Subjects: acute respiratory distress syndrome; Antiparasitic agents; cerebral malaria; Chemokines; Cognitive ability; Cytokines; Drug dosages; immunoregulation; Infections; Infectious diseases; Inflammation; Leukocytes; Lungs; Malaria; Mortality; N-(coumarin-3-yl)cinnamamide; Plasmodium berghei ANKA; acute respiratory distress syndrome; immunoregulation; N-(coumarin-3-yl)cinnamamide; cerebral malaria; Plasmodium berghei ANKA
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph17010046

ANKA (PbA) infection in mice resembles several aspects of severe malaria in humans, such as cerebral malaria and acute respiratory distress syndrome. Herein, the effects of -(coumarin-3-yl)cinnamamide (M220) against severe experimental malaria have been investigated. Treatment with M220 proved to protect cognitive abilities and lung function in PbA-infected mice, observed by an object recognition test and spirometry, respectively. In addition, treated mice demonstrated decreased levels of brain and lung inflammation. The production and accumulation of microglia, and immune cells that produce the inflammatory cytokines TNF and IFN-γ, decreased, while the production of the anti-inflammatory cytokine IL-10 by innate and adaptive immune cells was enhanced. Treatment with M220 promotes immunomodulatory, neuroprotective, and lung function-preserving effects during experimental severe malaria. Therefore, it may be an interesting therapeutic candidate to treat severe malaria effects.