Curcumin analog L3 alleviates diabetic atherosclerosis by multiple effects

• Published in: European journal of pharmacology Vol. 775; pp. 22 - 34
• Main Authors: Zheng, Bin, Yang, Liu, Wen, Caixia, Huang, Xiuwang, Xu, Chenxia, Lee, Kuan-Han, Xu, Jianhua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2016
• Subjects: Analog of curcumin; Animals; Aorta - drug effects; Aorta - metabolism; Aorta - pathology; Atherosclerosis - drug therapy; Atherosclerosis - etiology; Atherosclerosis - metabolism; Atherosclerosis - pathology; Curcumin - analogs & derivatives; Curcumin - pharmacology; Curcumin - therapeutic use; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diabetic atherosclerosis; Diet, High-Fat; Dyslipidemia; Hyperglycemia; Hyperglycemia - drug therapy; Hyperlipidemias - drug therapy; Hypoglycemic Agents - pharmacology; Hypoglycemic Agents - therapeutic use; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; Liver - drug effects; Liver - metabolism; Liver - pathology; Mice; Nitric Oxide - blood; Nitric Oxide - metabolism; Nitric Oxide Synthase - metabolism; Oxidative Stress - drug effects; Pancreas - drug effects; Pancreas - metabolism; Reactive Oxygen Species - metabolism; Scavenger Receptors, Class E - metabolism; NO; Dyslipidemia; MDA; LOX-1; Diabetic atherosclerosis; Hyperglycemia; Analog of curcumin; STZ; HCHF; iNOS; GSH; PBS; GHb; LDL-c; H&E; L3; SOD; GST; TBARS; GPx; TC; HDL-c; DCFH-DA; TG; ROS; CAT; IGT; TNOS; OGTT; DA; CHD
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/j.ejphar.2016.02.016

L3, an analog of curcumin, is a compound isolated from a traditional Chinese medicine Turmeric. In this paper, we aims to explore the efficacy of L3 on diabetic atherosclerosis and the related mechanism. The effect of L3 was studied on glucose and lipid metabolism, antioxidant status, atherosclerosis-related indexes and pathological changes of main organs in the mice model of diabetes induced by streptozotocin and high-fat diet. The results showed that L3 treatment could meliorate dyslipidemia and hyperglycemia, reduce oxidative stress, enhance the activity of antioxidases, increase the nitric oxide level in plasma and aortic arch, decrease the production of reactive oxygen species in pancreas and lectin-like oxidized low-density lipoprotein receptor-1 expression in aortic arch, and meliorate the fatty and atherosclerotic degeneration in aortic arch, thereby preventing the development of diabetes and its complications. These results suggested that L3 can alleviate the diabetic atherosclerosis by multiple effects. This study provided scientific basis for the further research and clinical application of L3. [Display omitted]