Survival from first recurrence: relative importance of prognostic factors in 1,015 breast cancer patients

Univariate and multivariate analyses of potential prognostic factors for 1,015 women with recurrent breast cancer confirmed that the site of initial recurrence is an important determinant for predicting survival from the time of initial recurrence. However, both estrogen receptor (ER) status and axi...

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Bibliographic Details
Published inJournal of clinical oncology Vol. 5; no. 1; p. 55
Main Authors Clark, G M, Sledge, Jr, G W, Osborne, C K, McGuire, W L
Format Journal Article
LanguageEnglish
Published United States 01.01.1987
Subjects
Adult
Aged
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Data Collection
Female
Humans
Menopause
Middle Aged
Models, Biological
Neoplasm Metastasis
Neoplasm Recurrence, Local - mortality
Prognosis
Receptors, Estrogen - analysis
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Summary:Univariate and multivariate analyses of potential prognostic factors for 1,015 women with recurrent breast cancer confirmed that the site of initial recurrence is an important determinant for predicting survival from the time of initial recurrence. However, both estrogen receptor (ER) status and axillary lymph node status at diagnosis, as well as the length of the disease-free interval, provide additional independent information for predicting patient survival after disease recurrence. Involved axillary lymph nodes at the time of initial diagnosis and/or lack of ERs may indicate a highly malignant tumor or a weak host defense, either of which might be related to short survival after relapse. Patients with ER-negative tumors recurred more often in visceral and soft-tissue sites, while patients with ER-positive tumors were more likely to recur in bony sites. However, for each metastatic site, receptor-positive patients had longer survival
ISSN:0732-183X
DOI:10.1200/jco.1987.5.1.55