Combination of retinoid and histone deacetylase inhibitor produced an anti-tumor effect in cutaneous T-cell lymphoma by restoring tumor suppressor gene, retinoic acid receptorβ2, via histone acetylation

• Published in: Journal of dermatological science Vol. 81; no. 1; pp. 17 - 25
• Main Authors: Kato, Yukihiko, Egusa, Chizu, Maeda, Tatsuo, Tsuboi, Ryoji
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.01.2016
• Subjects: Acetylation - drug effects; Animals; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Apoptosis - drug effects; Benzamides - administration & dosage; Benzoates - administration & dosage; Cell Line, Tumor; Cell Proliferation - drug effects; Cutaneous T cell lymphoma; Dermatology; DNA methylation; Female; Genes, Tumor Suppressor - drug effects; Histone acetylation; Histone Deacetylase Inhibitors - administration & dosage; Histones - metabolism; Humans; Lymphoma, T-Cell, Cutaneous - drug therapy; Lymphoma, T-Cell, Cutaneous - genetics; Lymphoma, T-Cell, Cutaneous - pathology; Mice; Mice, Inbred NOD; Mice, SCID; Promoter Regions, Genetic - drug effects; Pyridines - administration & dosage; Receptors, Retinoic Acid - genetics; Retinoic acid receptor; Retinoids - administration & dosage; Skin Neoplasms - drug therapy; Skin Neoplasms - genetics; Skin Neoplasms - pathology; Tetrahydronaphthalenes - administration & dosage; Xenograft Model Antitumor Assays; RAR; CTCL; DNA methylation; retinoid X receptors; cutaneous T cell lymphoma; Histone acetylation; histone deacetylase; RXR; retinoic acid receptor; HDAC; Cutaneous T cell lymphoma; Retinoic acid receptor
• ISSN: 0923-1811; 1873-569X
• DOI: 10.1016/j.jdermsci.2015.10.016

Highlights • Tumor suppressor gene, retinoic acid receptor β2 (RARβ2), was suppressed in CTCL. • The combination of retinoid with histone acetylation agent restored RARβ2 in CTCL. • The combination treatment inhibited cell growth by apoptosis in vitro. • The combination treatment suppressed tumor growth and prolonged survival in vivo. • This is first report of histone acetylation as primary in restoration of RARβ2.