Preserving the emetic effect of syrup of ipecac with concurrent activated charcoal administration: a preliminary study

• Published in: Journal of toxicology. Clinical toxicology Vol. 24; no. 2; p. 159
• Main Authors: Krenzelok, E P, Freedman, G E, Pasternak, S
• Format: Journal Article
• Language: English
• Published: United States 1986
• Subjects: Adult; Charcoal - administration & dosage; Charcoal - pharmacology; Drug Administration Schedule; Drug Synergism; Female; Humans; Intubation, Gastrointestinal; Ipecac - administration & dosage; Ipecac - antagonists & inhibitors; Male; Vomiting - chemically induced
• ISSN: 0731-3810
• DOI: 10.3109/15563658608990454

Activated charcoal is reported to block the emetic effect of syrup of ipecac. Therefore, activated charcoal administration is commonly delayed until syrup of ipecac induced emesis is complete. The advantages of early administration of activated charcoal have been well documented. Preservation of the emetic effect of syrup of ipecac in the presence of activated charcoal may produce a synergistic effect by enhancing toxin elimination. A study was conducted in ten human volunteers to determine if activated charcoal prevents the emetic effect of syrup of ipecac when a temporal separation exists between administration of the two substances. Syrup of ipecac 60 ml plus water 480 ml was administered via an 18 French nasogastric tube followed by an aqueous slurry of activated charcoal 50 g five minutes later. Eight (80%) of the subjects had emesis in a mean time of 20.25 minutes (range 16-26 min). The total dose of activated charcoal was retained for a mean time of 6.75 minutes (range 0-17 min). Two subjects (20%) failed to have emesis. This study illustrates that activated charcoal may not completely block the emetic effect of syrup of ipecac.