Lack of association of mirSNP rs11174811 in AVPR1A gene with arterial blood pressure and hypertension in South Indian population

• Published in: Clinical and experimental hypertension (1993) Vol. 40; no. 6; pp. 534 - 538
• Main Authors: Koshy, Linda, Vijayalekshmi, S. V., Harikrishnan, S., Raman, Kutty V., Jissa, V. T., Jayakumaran Nair, A., Gangaprasad, A., Nair, G. M, Sudhakaran, P. R.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.08.2018; Taylor & Francis Group
• Subjects: 3' Untranslated Regions; Aged; Alleles; Arterial Pressure - genetics; AVPR1A gene; blood pressure; Blood Pressure - genetics; Blood Pressure Determination; Case-Control Studies; censored normal regression; Cohort Studies; Epigenesis, Genetic; essential hypertension; European Continental Ancestry Group - genetics; Female; Gene Frequency; Genotype; Humans; Hypertension - genetics; India; Logistic Models; Male; microRNA; Middle Aged; Mirsnp; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptors, Vasopressin - genetics; regression; Renin-Angiotensin System - genetics; blood pressure; regression; essential hypertension; microRNA; censored normal regression; Mirsnp; AVPR1A gene
• ISSN: 1064-1963; 1525-6006
• DOI: 10.1080/10641963.2017.1403624

Epigenetic regulation of arterial blood pressure mediated through mirSNPs in renin-angiotensin aldosterone system (RAAS) genes is a less explored hypothesis. Recently, the mirSNP rs11174811 in the 3'UTR of the AVPR1A gene was associated with higher arterial blood pressure in a large study population from the Study of Myocardial Infarctions Leiden (SMILE). The aim of the present study was to replicate the association of mirSNP rs11174811 with blood pressure outcomes and hypertension in a south Indian population. Four hundred and fifteen hypertensive cases and 416 normotensive controls were genotyped using a 5' nuclease allelic discrimination assay. Logistic regression was used to test the association of mirSNP rs11174811 with the hypertension phenotype. Censored normal regression was used to test the association of the polymorphism with continuous blood pressure outcomes such as systolic and diastolic blood pressure. The mirSNP rs11174811 did not show any significant association with hypertension. The adjusted odds ratio was 1.02, with 95% CI of 0.72 to 1.45 (p = 0.909). The mean systolic and diastolic blood pressure values were not significantly different across the three genotypic groups, between hypertensives and normotensives, or when stratified by gender. Despite having a similar minor allele frequency (MAF) of 14.5% compared with the SMILE cohort, our results did not support an association of the mirSNP rs11174811 with the hypertension phenotype or with continuous blood pressure outcomes in the south Indian population.