Neutralization of Human Papillomavirus Type 11 (HPV-11) by Serum from Women Vaccinated with Yeast-Derived HPV-11 L1 Virus-like Particles: Correlation with Competitive Radioimmunoassay Titer

Neutralization of human papillomavirus type 11 (HPV-11) has been demonstrated using serum and cervical secretions from primates vaccinated with virus-like particles (VLPs). Theoretically, neutralizing antibodies could protect women from HPV infection. The immunogenicity of a yeast-derived HPV-11 L1...

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Published inThe Journal of infectious diseases Vol. 184; no. 9; pp. 1183 - 1186
Main Authors Brown, Darron R., Bryan, Janine T., Schroeder, Jill M., Robinson, Tiffany S., Fife, Kenneth H., Wheeler, Cosette M., Barr, Eliav, Smith, Paula R., Chiacchierini, Lisa, DiCello, Anthony, Jansen, Kathrin U.
Format Journal Article
LanguageEnglish
Published Chicago, IL The University of Chicago Press 01.11.2001
University of Chicago Press
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Abstract Neutralization of human papillomavirus type 11 (HPV-11) has been demonstrated using serum and cervical secretions from primates vaccinated with virus-like particles (VLPs). Theoretically, neutralizing antibodies could protect women from HPV infection. The immunogenicity of a yeast-derived HPV-11 L1 VLP vaccine was tested in women. Serum specimens were evaluated for HPV-11 titer by competitive radioimmunoassay (cRIA) and for neutralization by use of the athymic mouse xenograft system. Analysis of serum from 104 subjects showed a dose response in HPV-11 cRIA titers and neutralization. Overall, 68 (82.9%) of 82 postimmunization serum specimens from VLP recipients were 100% neutralizing when used in the assay at a 1:50 dilution. Of 69 serum specimens, 63 (91.3%) with cRIA titers >200 milliMerck units per milliliter were neutralizing. Immunization with HPV VLPs elicits a vigorous serum immune response in a high percentage of women. The HPV-11 cRIA titer appears to be a surrogate marker for neutralization
AbstractList Neutralization of human papillomavirus type 11 (HPV-11) has been demonstrated using serum and cervical secretions from primates vaccinated with virus-like particles (VLPs). Theoretically, neutralizing antibodies could protect women from HPV infection. The immunogenicity of a yeast-derived HPV-11 L1 VLP vaccine was tested in women. Serum specimens were evaluated for HPV-11 titer by competitive radioimmunoassay (cRIA) and for neutralization by use of the athymic mouse xenograft system. Analysis of serum from 104 subjects showed a dose response in HPV-11 cRIA titers and neutralization. Overall, 68 (82.9%) of 82 postimmunization serum specimens from VLP recipients were 100% neutralizing when used in the assay at a 1:50 dilution. Of 69 serum specimens, 63 (91.3%) with cRIA titers >200 milliMerck units per milliliter were neutralizing. Immunization with HPV VLPs elicits a vigorous serum immune response in a high percentage of women. The HPV-11 cRIA titer appears to be a surrogate marker for neutralization
Neutralization of human papillomavirus type 11 (HPV-11) has been demonstrated using serum and cervical secretions from primates vaccinated with virus-like particles (VLPs). Theoretically, neutralizing antibodies could protect women from HPV infection. The immunogenicity of a yeast-derived HPV-11 L1 VLP vaccine was tested in women. Serum specimens were evaluated for HPV-11 titer by competitive radioimmunoassay (cRIA) and for neutralization by use of the athymic mouse xenograft system. Analysis of serum from 104 subjects showed a dose response in HPV-11 cRIA titers and neutralization. Overall, 68 (82.9%) of 82 postimmunization serum specimens from VLP recipients were 100% neutralizing when used in the assay at a 1: 50 dilution. Of 69 serum specimens, 63 (91.3%) with cRIA titers >200 milliMerck units per milliliter were neutralizing. Immunization with HPV VLPs elicits a vigorous serum immune response in a high percentage of women. The HPV-11 cRIA titer appears to be a surrogate marker for neutralization.
Neutralization of human papillomavirus type 11 (HPV-11) has been demonstrated using serum and cervical secretions from primates vaccinated with virus-like particles (VLPs). Theoretically, neutralizing antibodies could protect women from HPV infection. The immunogenicity of a yeast-derived HPV-11 L1 VLP vaccine was tested in women. Serum specimens were evaluated for HPV-11 titer by competitive radioimmunoassay (cRIA) and for neutralization by use of the athymic mouse xenograft system. Analysis of serum from 104 subjects showed a dose response in HPV-11 cRIA titers and neutralization. Overall, 68 (82.9%) of 82 postimmunization serum specimens from VLP recipients were 100% neutralizing when used in the assay at a 1:50 dilution. Of 69 serum specimens, 63 (91.3%) with cRIA titers >200 milliMerck units per milliliter were neutralizing. Immunization with HPV VLPs elicits a vigorous serum immune response in a high percentage of women. The HPV-11 cRIA titer appears to be a surrogate marker for neutralization.
Author Barr, Eliav
Jansen, Kathrin U.
Fife, Kenneth H.
Brown, Darron R.
Schroeder, Jill M.
Chiacchierini, Lisa
Robinson, Tiffany S.
Bryan, Janine T.
DiCello, Anthony
Smith, Paula R.
Wheeler, Cosette M.
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Issue 9
Keywords Human
Yeast
Antibody
Secretion
Use
Vaccination
Rodentia
Vaccine
Papovaviridae
Female genital diseases
Papillomavirus
Virus
Vertebrata
Human papillomavirus
Mammalia
Immunogenicity
Mouse
Radioimmunoassay
Primates
Female
Serum
Cervicitis
Uterine cervix diseases
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Snippet Neutralization of human papillomavirus type 11 (HPV-11) has been demonstrated using serum and cervical secretions from primates vaccinated with virus-like...
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SubjectTerms Adolescent
Adult
Animals
Antibodies, Viral - blood
Antibodies, Viral - immunology
Biological and medical sciences
Dose-Response Relationship, Drug
Double-Blind Method
Female
Human papillomavirus 11
Human viral diseases
Humans
Infectious diseases
Medical sciences
Mice
Neutralization Tests
Papillomaviridae - genetics
Papillomaviridae - immunology
Papillomavirus Infections - prevention & control
Papillomavirus Infections - virology
Radioimmunoassay
Tumor Virus Infections - prevention & control
Tumor Virus Infections - virology
Vaccination
Vaccines, Synthetic - immunology
Viral diseases
Viral diseases of the genital and urinary system
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Vaccines - immunology
Virion - immunology
Yeasts - genetics
Title Neutralization of Human Papillomavirus Type 11 (HPV-11) by Serum from Women Vaccinated with Yeast-Derived HPV-11 L1 Virus-like Particles: Correlation with Competitive Radioimmunoassay Titer
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