Hsa_circ_0037897 may be a risk factor for essential hypertension via hsa-miR-145-5p

• Published in: Clinical and experimental hypertension (1993) Vol. 43; no. 3; pp. 281 - 286
• Main Authors: Tao, Zhenbo, Zheng, Shuying, He, Xin, Sun, Jihan, He, Canxia, Zhang, Lina
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2021; Taylor & Francis Group
• Subjects: Adult; Aged; Area Under Curve; Biomarkers - metabolism; Case-Control Studies; circRNA; diagnostic value; essential hypertension; Essential Hypertension - diagnosis; Essential Hypertension - genetics; Factor Analysis, Statistical; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Logistic Models; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Reproducibility of Results; risk factor; Risk Factors; RNA, Circular - genetics; RNA, Circular - metabolism; ROC Curve; essential hypertension; miRNA; circRNA; diagnostic value; risk factor
• ISSN: 1064-1963; 1525-6006; 1525-6006
• DOI: 10.1080/10641963.2020.1860081

Objectives: This study aims to investigate the association between hsa_circ_0037897 and essential hypertension (EH) and to evaluate the diagnostic value of biomarker hsa_circ_0037897 in EH. Methods: This study included 92 EH patients and 92 sex- and age- (±3 years) matched subjects as control. qRT-PCR was performed to measure the expression level of circRNA and miRNA. Logistic regression analysis model was used to assess independent association between hsa_circ_0037897 and EH. Results: The expression level of hsa_circ_0037897 in EH patients was significantly higher (p < .001) compared to the control group, while hsa-miR-145-5p had significantly lower expression(p = .002) than the control group. The area under the ROC curve (AUC) of hsa_circ_0037897 was 0.656. Furthermore, the AUC increased to 0.714 when hsa_circ_0037897 was combined with hsa-miR-145-5p, BMI and smoking. Conclusion: The present results suggested that the high expression of hsa_circ_0037897 may be a risk factor for EH, and hsa_circ_0037897 has certain diagnostic value for EH.