In vitro biocompatibility and corrosion resistance of a new implant titanium base alloy

• Published in: Journal of materials science. Materials in medicine Vol. 21; no. 6; pp. 1959 - 1968
• Main Authors: Vasilescu, E., Drob, P., Raducanu, D., Cojocaru, V. D., Cinca, I., Iordachescu, D., Ion, R., Popa, M., Vasilescu, C.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2010; Springer; Springer Nature B.V
• Subjects: Alloys - pharmacology; Biocompatibility; Biological and medical sciences; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Body Fluids - drug effects; Ceramics; Chemistry and Materials Science; Composites; Corrosion; Corrosion resisting materials; Glass; Humans; Isotonic Solutions; Materials Science; Medical sciences; Natural Materials; Osteoblasts - drug effects; Polymer Sciences; Prostheses and Implants; Regenerative Medicine/Tissue Engineering; Surfaces and Interfaces; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Thin Films; Titanium - chemistry; Titanium aluminum alloys; Final Heat Treatment; Corrosion Behaviour; Open Circuit Potential; Corrosion Rate; Ringer Solution; Physiological condition; Human; Biological properties; Titanium alloy; Implant; Prosthesis; In vitro; Osteoarticular system; Corrosion resistance; Orthopedic surgery; Osteoblast; Biocompatibility; Fetus; Biomaterial; Bone; Biomedical engineering
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-010-4057-x

One objective of this work was to study the corrosion resistance of the new implant Ti–10Zr–5Ta–5Nb alloy in physiological fluids of different pH values, simulating the extreme functional conditions. Another objective was in vitro biocompatibility evaluation of the new alloy using human fetal osteoblast cell line hFOB 1.19. Cytocompatibility was assessed by determination of possible material cytotoxic effects, cell morphology and cell adhesion. The thermo-mechanical processing of the new implant alloy consisted in plastic deformation (almost 90%) performed by hot rolling accompanied by an initial and final heat treatment. The new Ti–10Zr–5Ta–5Nb alloy presented self-passivation, with a large passive potential range and low passive current densities, namely, a very good anticorrosive resistance in Ringer solution of acid, neutral and alkaline pH values. Cell viability was not affected by the alloy substrate presence and a very good compatibility was noticed.