Study on the Mechanism of Maternal Imprinting During Oocyte Growth

In mammals, both parental genomes are essential for normal ontogeny because epigenetic modifications imposed in the parents' gametes lead to parent-of-origin specific gene expression in their offspring. These phenomena are referred to as genomic imprinting. It has been shown that maternal impri...

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Bibliographic Details
Published inJournal of Reproduction and Development Vol. 57; no. 1; pp. 1 - 8
Main Author OBATA, Yayoi
Format Journal Article
LanguageEnglish
Published Japan THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT 2011
Subjects
Animals
Embryo, Mammalian - metabolism
Embryonic Development - genetics
Female
Genomic Imprinting
Humans
Male
Mothers
Nuclear transfer
Oocyte
Oocytes - growth & development
Oocytes - metabolism
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Summary:In mammals, both parental genomes are essential for normal ontogeny because epigenetic modifications imposed in the parents' gametes lead to parent-of-origin specific gene expression in their offspring. These phenomena are referred to as genomic imprinting. It has been shown that maternal imprinting is established during oocyte growth, lack of maternal imprinting in zygotes leads to early embryonic death, and in vitro system that allows establishment of maternal imprinting is developed. In this review, I describe the history of the discovery of genomic imprinting, the regulatory mechanisms of mammalian development by maternal imprinting, and the molecular mechanisms of genomic imprinting.
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.10-195E