Detection of gene rearrangements in reactive lymphoid processes

We report the immunohistologic and the genotypic analysis of lymph node biopsies from 23 cases of reactive processes, and two cases of atypical lymphoproliferations (AL). Clonal gene rearrangements were detected in 5 cases of proven reactive processes as well as in both AL, in which no signs of mali...

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Bibliographic Details
Published inLeukemia & lymphoma Vol. 9; no. 1-2; p. 103
Main Authors Orphanos, V, Anagnostou, D, Papadaki, T, Maniatis, G M, Athanassiadou, A
Format Journal Article
LanguageEnglish
Published United States 01.01.1993
Subjects
Antigens, CD - analysis
Autoimmune Diseases - pathology
Biopsy
Clone Cells - pathology
Gene Rearrangement
Gene Rearrangement, B-Lymphocyte
Gene Rearrangement, T-Lymphocyte
Genes, Immunoglobulin
Humans
Hyperplasia
Immunophenotyping
Infection - pathology
Lymph Nodes - pathology
Lymphoproliferative Disorders - genetics
Lymphoproliferative Disorders - pathology
Oligonucleotide Probes
Receptors, Antigen, T-Cell - genetics
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Summary:We report the immunohistologic and the genotypic analysis of lymph node biopsies from 23 cases of reactive processes, and two cases of atypical lymphoproliferations (AL). Clonal gene rearrangements were detected in 5 cases of proven reactive processes as well as in both AL, in which no signs of malignancy were detected during the phenotypic analysis. No patient, apart from the two AL cases, showed any progression to malignancy during a follow-up period of 28-43 months after the initial biopsy.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428199309148511