The effect of oil and water-soluble contrast medium in hysterosalpingography on thyroid function

• Published in: Gynecological endocrinology Vol. 33; no. 9; pp. 682 - 685
• Main Authors: So, Shuhei, Yamaguchi, Wakasa, Tajima, Hiroko, Nakayama, Takeshi, Tamura, Naoaki, Kanayama, Naohiro, Tawara, Fumiko
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.09.2017
• Subjects: Adult; Contrast Media - administration & dosage; Contrast Media - adverse effects; Female; Humans; Hypothyroidism - blood; Hypothyroidism - chemically induced; Hysterosalpingography; Hysterosalpingography - adverse effects; Hysterosalpingography - methods; infertility; oil-soluble contrast medium; subclinical hypothyroidism; Thyroid Gland - drug effects; Thyrotropin - blood; Thyroxine - blood; water-soluble contrast medium; oil-soluble contrast medium; water-soluble contrast medium; Hysterosalpingography; infertility; subclinical hypothyroidism
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590.2017.1307960

Hysterosalpingography (HSG) using iodinated contrast medium is X-ray diagnostic test that examines the inside of the uterus and fallopian tubes in infertile women. In this study, we compared thyroid function (thyroid stimulating hormone: TSH and free-T4: FT4 levels) after HSG with an oil-soluble contrast medium (OSCM) and a water-soluble contrast medium (WSCM). One hundred and sixty-four and 94 patients with normal thyroid function received HSG with OSCM and WSCM, respectively. Approximately 25% of the women in the OSCM group developed subclinical hypothyroidism (SCH), whereas only less than 10% of the patients in the WSCM group developed SCH. Our data clearly indicate that WSCM is safe for thyroid function in women who plan to get pregnant.