Porphyromonas gingivalis promotes the cell cycle and inflammatory cytokine production in periodontal ligament fibroblasts

Highlights • We established the model of P. gingivalis infected human primary PDLFs. • P. gingivalis enhanced the proliferation and G1 phase of PDLFs. • P. gingivalis induced the decrease of p21 and increase of cyclin D1 and cyclin E. • P. gingivalis promoted the expressions of IL-6 and IL-8 of PDLF...

Full description

Saved in:
Bibliographic Details
Published inArchives of oral biology Vol. 60; no. 8; pp. 1153 - 1161
Main Authors Liu, Junchao, Tang, Xiaolin, Li, Chen, Pan, Chunling, Li, Qian, Geng, Fengxue, Pan, Yaping
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2015
Subjects
Advanced Basic Science
Blotting, Western
Cell Cycle
Cell Proliferation
Cells, Cultured
Cyclin D1 - metabolism
Cyclin E - metabolism
Cyclin-Dependent Kinase Inhibitor p21 - metabolism
Cytokines
Dentistry
Enzyme-Linked Immunosorbent Assay
Fibroblasts - metabolism
Flow Cytometry
Humans
Periodontal Ligament - cytology
Periodontal ligament fibroblasts
Periodontitis
Porphyromonas gingivalis
Porphyromonas gingivalis - immunology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Up-Regulation
Porphyromonas gingivalis
Periodontal ligament fibroblasts
Cytokines
Periodontitis
Cell cycle
Online AccessGet full text

Cover

More Information
Summary:Highlights • We established the model of P. gingivalis infected human primary PDLFs. • P. gingivalis enhanced the proliferation and G1 phase of PDLFs. • P. gingivalis induced the decrease of p21 and increase of cyclin D1 and cyclin E. • P. gingivalis promoted the expressions of IL-6 and IL-8 of PDLFs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.05.004