Multiple cardiac metastases from a nonfunctioning pancreatic neuroendocrine tumor

• Published in: Cancer research and treatment Vol. 45; no. 2; pp. 150 - 154
• Main Authors: Choi, Yong Hyeok, Han, Hye-Suk, Lim, Sung-Nam, Lee, Sang Yeub, Koo, Ji Hae, Lee, Ok-Jun, Lee, Ki Hyeong, Kim, Seung Taik
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Cancer Association 01.06.2013; 대한암학회
• Subjects: Case Report; 의약학; Neoplasm metastasis; Pancreas; Heart neoplasms; Neuroendocrine tumors
• ISSN: 1598-2998; 2005-9256
• DOI: 10.4143/crt.2013.45.2.150

Pancreatic neuroendocrine tumors (pNETs) are rare neoplasms, which most commonly metastasize to the liver. However, intrathoracic metastases from pNETs are encountered infrequently. This report describes a case of nonfunctioning pNET with multiple cardiac metastases. A 56-year-old male presented with a palpable abdominal mass that showed progressive enlargement. Findings on computed tomography (CT) of the abdomen revealed two relatively well-marginated inhomogeneous low-attenuation masses, one in the head of the pancreas and the other in the tail. Multiple enhancing masses in the left pericardium with myocardial involvement were observed on chest CT and transthoracic echocardiography. Needle biopsies were performed on the mass in the tail of the pancreas and the left ventricular apical pericardium; histologic examination by hematoxylin and eosin morphology and immunohistochemical staining showed pNET in both. This is the first report of pNET with multiple cardiac metastases to previously undescribed metastatic sites.