Cytotoxic and antimicrobial flavonoids from Cryptocarya concinna

• Published in: Planta medica Vol. 80; no. 11; p. 925
• Main Authors: Huang, Wei, Zhang, Wen-Jing, Cheng, Yi-Qing, Jiang, Rong, Wei, Wei, Chen, Chao-Jun, Wang, Gang, Jiao, Rui-Hua, Tan, Ren-Xiang, Ge, Hui-Ming
• Format: Journal Article
• Language: English
• Published: Germany 01.07.2014
• Subjects: Anti-Infective Agents - chemistry; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Botrytis - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Cryptocarya - chemistry; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Flavonoids - chemistry; Flavonoids - isolation & purification; Flavonoids - pharmacology; Fusarium - drug effects; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Plant Stems - chemistry
• ISSN: 1439-0221
• DOI: 10.1055/s-0034-1368613

Five new flavonoids, cryptoconones A-E (1-5), along with six known compounds (6-11), were isolated from the stems of Cryptocarya concinna. The structures of these compounds were elucidated on the basis of spectroscopic data interpretation, and the absolute configurations were determined via circular dichroism spectra and X-ray crystal analysis. The cytotoxic and antimicrobial activities of these compounds were also evaluated. Compounds 9 and 10 exhibited moderate cytotoxic activities against HCT116, HT-29, SW480, and MDA-MB-231 cell lines with IC50 values ranging from 6.25 to 9.35 µM. Compounds 8 and 11 exhibited antimicrobial activity against Fusarium moniliforme and Botrytis cinerea, respectively, with the same minimum inhibitory concentration of 5 µg/mL.