An electrochemical deamidated gliadin antibody immunosensor for celiac disease clinical diagnosis

The first electrochemical immunosensor (EI) for the detection of antibodies against deamidated gliadin peptides (DGP) is described here. A disposable nanohybrid screen-printed carbon electrode modified with DGP was employed as the transducer's sensing surface. Real serum samples were successful...

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Bibliographic Details
Published inAnalyst (London) Vol. 138; no. 7; pp. 1956 - 1958
Main Authors Neves, Marta M. P. S, González-García, María Begoña, Nouws, Henri P. A, Costa-García, Agustín
Format Journal Article
LanguageEnglish
Published England 07.04.2013
Subjects
Antibodies - blood
Biosensing Techniques - methods
Celiac Disease - diagnosis
Celiac Disease - immunology
Gliadin - immunology
Gliadin - metabolism
Humans
Immunoassay - methods
Immunoglobulin G - analysis
Nanotubes, Carbon
Peptide Fragments - immunology
Transglutaminases - metabolism
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Summary:The first electrochemical immunosensor (EI) for the detection of antibodies against deamidated gliadin peptides (DGP) is described here. A disposable nanohybrid screen-printed carbon electrode modified with DGP was employed as the transducer's sensing surface. Real serum samples were successfully assayed and the results were corroborated with an ELISA kit. The presented EI is a promising analytical tool for celiac disease diagnosis. The first electrochemical immunosensor (EI) for the detection of antibodies against deamidated gliadin peptides (DGP) is described here.
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ISSN:0003-2654
1364-5528
DOI:10.1039/c3an36728b