Development of collagenous colitis in sequential biopsy specimens

The present report describes the morphologic findings in sequential colorectal biopsy specimens obtained from 2 patients who within 1.5-2.5 yr developed collagenous colitis. The initial biopsy specimens revealed an acute nonspecific inflammatory reaction in the colorectal mucosa. An intermediate sta...

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Bibliographic Details
Published inGastroenterology (New York, N.Y. 1943) Vol. 87; no. 3; p. 703
Main Authors Teglbjaerg, P S, Thaysen, E H, Jensen, H H
Format Journal Article
LanguageEnglish
Published United States 01.09.1984
Subjects
Aged
Biopsy
Colitis - pathology
Collagen - analysis
Female
Humans
Immunoenzyme Techniques
Intestinal Mucosa - analysis
Intestinal Mucosa - pathology
Rectum - pathology
Time Factors
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Summary:The present report describes the morphologic findings in sequential colorectal biopsy specimens obtained from 2 patients who within 1.5-2.5 yr developed collagenous colitis. The initial biopsy specimens revealed an acute nonspecific inflammatory reaction in the colorectal mucosa. An intermediate stage, characterized by edema and slight fibrosis in the subepithelial region of the colorectal mucosa, preceded the final development of collagenous colitis. We suggest that the mechanism that leads to the formation of a thick, bandlike subepithelial collagenous deposit in the colorectal mucosa may be triggered off by some inflammatory or toxic stimulus.
ISSN:0016-5085
DOI:10.1016/0016-5085(84)90546-8