Microcytic Anemia

To the Editor: In the review of microcytic anemia by DeLoughery (Oct. 2 issue), 1 two commonly encountered causes of microcytic anemia and iron deficiency were not mentioned: chronic infection with Helicobacter pylori and the long-term use of proton-pump inhibitors (PPIs). 2 , 3 H. pylori is known t...

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Published inThe New England journal of medicine Vol. 371; no. 26; pp. 2535 - 2537
Main Authors Brodzik, Frank, Chikkappa, Gundabhaktha, Pasquale, Donald, Aviner, Shraga, Armoni-Sivan, Rinat, Bibi, Haim, Fonseca, Eduardo K.U.N, de Góis, Aécio F.T, DeLoughery, Thomas G
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 25.12.2014
Subjects
Acid production
Anemia
Anemia, Iron-Deficiency
Blood Transfusion
Chronic infection
Erythrocytes - pathology
Gastric juice
Helicobacter pylori
Humans
Infections
Iron
Iron - therapeutic use
Nutrient deficiency
Pathogens
Proton pump inhibitors
Thalassemia
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Summary:To the Editor: In the review of microcytic anemia by DeLoughery (Oct. 2 issue), 1 two commonly encountered causes of microcytic anemia and iron deficiency were not mentioned: chronic infection with Helicobacter pylori and the long-term use of proton-pump inhibitors (PPIs). 2 , 3 H. pylori is known to consume iron and thereby makes dietary iron unavailable for absorption. 4 Gastric acid is required for effective absorption of dietary iron, and PPIs, which inhibit acid production, may impair absorption. 2 It is our practice to consider screening all patients with iron-deficiency anemia for H. pylori infection and to consider withholding PPI therapy while patients are . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1413161