Underestimation of dose--response relationship with particular reference to the relationship between the dietary intake of mercury and its concentration in blood

Wide discrepancies have been observed between controlled and uncontrolled intake studies of the relationship of blood mercury concentration to intake of mercury. The probable reason for the apparent discrepancies is that the within-subject variation of mercury intake in the uncontrolled studies was...

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Bibliographic Details
Published inHuman & experimental toxicology Vol. 7; no. 2; pp. 129 - 132
Main Authors Sherlock, J C, Quinn, M J
Format Journal Article
LanguageEnglish
Published England 01.03.1988
Subjects
Analysis of Variance
Diet
Dose-Response Relationship, Drug
Environmental Exposure
Fish Products - analysis
Humans
Individuality
Mathematics
Mercury - analysis
Mercury - blood
Methylmercury Compounds - blood
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ISSN0144-5952
0960-3271
DOI10.1177/096032718800700204

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Summary:Wide discrepancies have been observed between controlled and uncontrolled intake studies of the relationship of blood mercury concentration to intake of mercury. The probable reason for the apparent discrepancies is that the within-subject variation of mercury intake in the uncontrolled studies was almost certainly considerably larger than the within-subject variation in blood mercury concentration; in these circumstances, the apparent slope obtained from a linear regression of blood mercury on intake will invariably be much smaller than the true slope. Studies of the exposure or intake of any substance should therefore include a consideration of the likely within-subject variation in the exposure or intake relative to that in the effect.
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ISSN:0144-5952
0960-3271
DOI:10.1177/096032718800700204