Avidity as a criterion for diagnosis of human strongyloidiasis increases specificity of IgG ELISA

This study evaluates the inclusion of the IgG avidity index in ELISA to detect anti-Strongyloides stercoralis IgG. The ELISA index revealed 70% of specificity. With the inclusion of screening AI, specificity increased to 80%. IgG avidity complemented traditional IgG ELISA by eliminating some of the...

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Published inDiagnostic microbiology and infectious disease Vol. 89; no. 4; pp. 262 - 264
Main Authors Bosqui, Larissa Rodrigues, Gonzaga, Henrique Tomaz, Gonçalves-Pires, Maria do Rosário de Fátima, de Paula, Fabiana Martins, Almeida, Ricardo Sergio, Pavanelli, Wander Rogério, Conchon-Costa, Ivete, Costa-Cruz, Julia Maria, da Costa, Idessania Nazareth
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.12.2017
Subjects
Animals
Antibodies, Helminth - blood
Antibody Affinity
Antigens, Helminth - blood
Avidity-ELISA
Cross-reaction
Enzyme-Linked Immunosorbent Assay
Humans
Immunoglobulin G - blood
Sensitivity and Specificity
Strongyloides - immunology
Strongyloides - isolation & purification
Strongyloides sp
Strongyloidiasis
Strongyloidiasis - diagnosis
Strongyloidiasis - immunology
Cross-reaction
Avidity-ELISA
Strongyloides sp
Strongyloidiasis
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Summary:This study evaluates the inclusion of the IgG avidity index in ELISA to detect anti-Strongyloides stercoralis IgG. The ELISA index revealed 70% of specificity. With the inclusion of screening AI, specificity increased to 80%. IgG avidity complemented traditional IgG ELISA by eliminating some of the suspected or false positive cases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2017.08.008