A 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat

• Published in: Nutrients Vol. 16; no. 8; p. 1137
• Main Authors: Shin, Seon Mi, Park, Jeong-Su, Kim, Sang Back, Cho, Young Hee, Seo, Hee, Lee, Hak Sung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.04.2024; MDPI
• Subjects: Absorptiometry, Photon; Acids; Adipose Tissue - drug effects; Adult; Antibiotics; Antidepressants; Bacteria; Birth control; Body fat; Clinical trials; Contraindications; Diabetes; Dietary supplements; Diuretics; Double-Blind Method; Drugs; Female; Food; Functional foods & nutraceuticals; Gastrointestinal Microbiome - drug effects; Genomes; Hospitals; Humans; Hypertension; Lactiplantibacillus plantarum SKO-001; Lactobacillus plantarum; Leptin - blood; Male; Metabolic disorders; Microbiota; Middle Aged; nutritional supplement; Obesity; Participation; placebo-controlled study; Probiotics; randomised controlled trial; Treatment Outcome; Weight control; placebo-controlled study; randomised controlled trial; nutritional supplement; Lactiplantibacillus plantarum SKO-001; obesity
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16081137

There is growing evidence linking gut microbiota to overall health, including obesity risk and associated diseases. SKO-001, a probiotic strain isolated from , has been reported to reduce obesity by controlling the gut microbiome. In this double-blind, randomised clinical trial, we aimed to evaluate the efficacy and safety of SKO-001 in reducing body fat. We included 100 participants randomised into SKO-001 or placebo groups (1:1) for 12 weeks. Dual-energy X-ray absorptiometry was used to objectively evaluate body fat reduction. Body fat percentage ( = 0.016), body fat mass ( = 0.02), low-density lipoprotein-cholesterol levels ( = 0.025), and adiponectin levels ( = 0.023) were lower in the SKO-001 group than in the placebo group after 12 weeks of SKO-001 consumption. In the SKO-001 group, the subcutaneous fat area ( = 0.003), total cholesterol levels ( = 0.003), and leptin levels ( = 0.014) significantly decreased after 12 weeks of SKO-001 consumption compared with baseline values. Additionally, SKO-001 did not cause any severe adverse reactions. In conclusion, SKO-001 is safe and effective for reducing body fat and has the potential for further clinical testing in humans.