Hypertension in women: the role of progesterone and aldosterone

The age-related course of blood pressure and its gender-related difference, as well as the incidence of hypertension, have been the subject of multiple experimental, clinical and epidemiological studies over the past decades. The role of the sex hormones estradiol and testosterone within this gender...

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Published inClimacteric : the journal of the International Menopause Society Vol. 13; no. 4; pp. 307 - 313
Main Authors Boschitsch, E., Mayerhofer, S., Magometschnigg, D.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.08.2010
Taylor & Francis
Taylor & Francis Ltd
Subjects
Aged
Aldosterone - adverse effects
Aldosterone - physiology
Androstenes - administration & dosage
Androstenes - therapeutic use
Animals
BLOOD PRESSURE
Cardiovascular Diseases - etiology
Diet, Sodium-Restricted
DROSPIRENONE
Estradiol - administration & dosage
Estrogens - adverse effects
Estrogens - pharmacology
Estrogens - physiology
Female
GENDER
Humans
HYPERTENSION
Hypertension - complications
Hypertension - drug therapy
Hypertension - prevention & control
MENOPAUSE
Middle Aged
Mineralocorticoid Receptor Antagonists - therapeutic use
Natriuresis
PROGESTERONE
Progesterone - physiology
Progesterone Congeners - adverse effects
Progesterone Congeners - pharmacology
Renin-Angiotensin System - drug effects
Renin-Angiotensin System - physiology
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
Risk Factors
SALT SENSITIVITY
Sex Characteristics
Women
Womens health
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Summary:The age-related course of blood pressure and its gender-related difference, as well as the incidence of hypertension, have been the subject of multiple experimental, clinical and epidemiological studies over the past decades. The role of the sex hormones estradiol and testosterone within this gender dimorphism has been investigated without conclusive results. In this review, we provide background information on the gender difference in blood pressure, describe the impact of progesterone and aldosterone, and discuss the pathophysiology of aldosteronism as well as the potential role of drospirenone as a gender-specific agent for the prevention and treatment of hypertension and for cardiovascular protection.
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ISSN:1369-7137
1473-0804
1473-0804
DOI:10.3109/13697131003624649