Poly(butylene adipate-co-terephthalate) scaffolds: processing, structural characteristics and cellular responses

• Published in: Journal of biomaterials science. Polymer ed. Vol. 27; no. 18; pp. 1841 - 1859
• Main Authors: Arslan, Aysu, Çakmak, Soner, Cengiz, Alper, Gümüşderelioğlu, Menemşe
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 11.12.2016
• Subjects: Biotechnology; bone tissue engineering; Bones; Electrospinning; Leaching; melt molding-particulate leaching; Poly(butylene adipate-co-terephthalate); scaffold; Scaffolds; solvent casting-particulate leaching; Solvents; Thermal properties; Tissue engineering; solvent casting-particulate leaching; melt molding-particulate leaching; bone tissue engineering; electrospinning; scaffold; Poly(butylene adipate-co-terephthalate)
• ISSN: 0920-5063; 1568-5624
• DOI: 10.1080/09205063.2016.1239945

The aliphatic-aromatic copolyester, poly(butylene adipate-co-terephthalate) (PBAT) combines good mechanical and thermal properties with biodegradation ability. However, until now, researches in its potential medical use remain limited. Only in a few studies blends of PBAT with routinely used biocompatible polymers had been prepared and investigated regarding tissue engineering applications. Therefore, in this study, we decided to determine processability of neat PBAT as a scaffold material for bone tissue by using different fabrication methods i.e. solvent evaporation, electrospinning, solvent casting-particulate leaching (SCPL) and melt molding-particulate leaching. The results of physicochemical characterizations and cell culture studies with MC3T3-E1 preosteoblasts confirmed that neat PBAT has favorable characteristics for bone tissue engineering, however, fabrication method strongly affects the cellular responses. Regarding to the characterizations and cell cultures, PBAT scaffolds produced by SCPL and electrospinning are proposed to be used for bone tissue engineering.