Is obesity associated with gastropharyngeal reflux disease

• Published in: World journal of gastroenterology : WJG Vol. 14; no. 2; pp. 265 - 271
• Main Authors: Choi, Cheol Woong, Kim, Gwang Ha, Song, Chul Soo, Wang, Soo Geun, Lee, Byung Joo, I, Hoseok, Kang, Dae Hwan, Song, Geun Am
• Format: Journal Article
• Language: English
• Published: United States Department of Internal Medicine,Pusan National University School of Medicine,Busan,Korea%Department of Otolaryngology,Pusan National University School of Medicine,Busan,Korea%Department of Chest Surgery,Pusan National University School of Medicine,Busan,Korea 14.01.2008; The WJG Press and Baishideng
• Subjects: Cross-Sectional Studies; Female; Gastric Acid; Gastroesophageal Reflux - epidemiology; Humans; Male; Manometry; Middle Aged; Obesity - epidemiology; Pharyngeal Diseases - epidemiology; Rapid Communication; Risk Factors; 体重指数; 胃食管反流疾病; Gastroesophageal reflux; Obesity; Body mass index; Gastropharyngeal reflux
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.14.265

AIM： To examine the association between obesity and gastropharyngeal reflux disease （GPRD） as well as gastroesophageal reflux disease （GERD） METHODS： We conducted a cross-sectional study of consecutive patients undergoing ambulatory 24-h dualprobe pH monitoring from July 2003 to December 2006. The association between body mass index （BMI） and parameters about gastroesophageal or gastropharyngeal reflux was examined in univariate and multivariate analyses. RESULTS： A total of 769 patients （307 men and 462 women; mean age 50.7 years） were finally enrolled. Most variables showing gastroesophageal reflux was higher in the obese patients than the patients with normal BMI. There was no difference in all the variables showing gastropharyngeal reflux according to the BMI. After adjustment for age, sex, alcohol intake and smoking, obese patients demonstrated an about 2-fold increase in risk of GERD compared with patients with normal BMI （OR, 1.9; 95 CI, 1.3-2.9）, but overweight patients did not demonstrate increased risk of GERD （OR, 1.2; 95 CI, 0.8-1.7）. Both obese patients and overweight patients did not demonstrated increased risk of GPRD compared with patients with normal BMI （OR, 1.1; 95 CI, 0.8-1.7; and OR, 0.9; 95 CI, 0.6-1.3, respectively）. CONCLUSION： Obesity is not associated with GPRD reflux while it is associated with GERD.