Cervical vestibular-evoked myogenic potential in vestibular schwannoma after gamma-knife surgery

• Published in: Auris, nasus, larynx Vol. 42; no. 4; pp. 265 - 270
• Main Authors: Lee, Yi-Fang, Lee, Cheng-Chia, Wang, Mao-Che, Liu, Kang-Du, Wu, Hsiu-Mei, Guo, Wan-Yuo, Shiao, An-Suey, Pan, David Hung-Chi, Chung, Wen-Yuh, Hsu, Sanford P.C
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.08.2015
• Subjects: Adult; Aged; Audiometry, Pure-Tone; Caloric test; Caloric Tests; Cohort Studies; Female; Gamma-knife; Humans; Male; Middle Aged; Neuroma, Acoustic - pathology; Neuroma, Acoustic - physiopathology; Neuroma, Acoustic - surgery; Otolaryngology; Prospective Studies; Radiosurgery; Radiosurgery - methods; Treatment Outcome; Tumor Burden; Vestibular evoked myogenic potential; Vestibular Evoked Myogenic Potentials - physiology; Vestibular schwannoma; Vestibular evoked myogenic potential; Caloric test; Gamma-knife; Radiosurgery; Vestibular schwannoma
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/j.anl.2015.01.004

Abstract Objective Gamma-knife radiosurgery (GKS) for vestibular schwannomas (VSs) has become popular during the last two decades, and a promising tumor control rate has been reported. Therefore, the evaluation and preservation of auditory-vestibular nerve function after GKS have become more and more important in these patients with long-term survival. We have traditionally used pure-tone audiometry (PTA) for evaluation of auditory nerve function, and the caloric test for superior vestibular nerve function. Vestibular-evoked myogenic potential (VEMP) has recently emerged from various neurophysiological examinations for assessment of the integrity of the inferior vestibular nerve function. This novel tool has been established to represent a sacculo-collic reflex. By using these three tools, the auditory-vestibular nerve function of VS patients can be evaluated and monitored before and after GKS. Methods Fourteen patients with unilateral VS that underwent GKS were prospectively recruited. All of them received a battery of auditory-vestibular function tests including PTA, caloric, and cVEMP tests before and after GKS at each time point (1, 6, and 12 months). Our data also included the tumor volumes and their relationship with the PTA, caloric, and cVEMP test results. Results The PTA, caloric, and cVEMP tests showed abnormal results before GKS in 85.7%, 78.6% and 78.6% of our VS patients, respectively. The PTA, caloric, and cVEMP results did not show strong correlations between each other. However, there was a tendency that when the tumor grew larger, the auditory-vestibular function deficits became more severe. The PTA and cVEMP test results remained stable during the 1-year follow-up after GKS. However, the caloric test showed transient deterioration at the 6th month follow-up, which then recovered by the 1-year follow-up. Conclusion The combination of these three tests can help us diagnose VS and assess the change in auditory-vestibular nerve function during the post-GKS follow-up period. The results of these three tests were independent for smaller tumors, but all tests may show abnormal findings with larger tumors. Although the study is still ongoing, the preliminary data showed that GKS treatment would not affect the auditory-vestibular nerve function within a 1-year follow-up period.