Case Report: Lateral Habenula Deep Brain Stimulation for Treatment-Resistant Depression

Treatment-resistant depression (TRD) is a chronic and severe psychiatric illness associated with limited therapeutic options. Deep brain stimulation (DBS) is a promising therapy for TRD patients. However, its safety and efficacy are still unclear. Here we reported the safety and efficacy of lateral...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in psychiatry Vol. 11; p. 616501
Main Authors Wang, Zhiyan, Cai, Xiaodong, Qiu, Rirang, Yao, Chen, Tian, Ye, Gong, Chen, Zhang, Yingli, Xu, Bin, Zhang, Doudou, Zang, Yu, Liu, Jiali, Peng, Bo, Li, Luming
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 13.01.2021
Subjects
deep brain stimualtion
lateral habenula
local field potentials
patient
Psychiatry
treatment resistant depression
deep brain stimualtion
treatment resistant depression
local field potentials
patient
lateral habenula
Online AccessGet full text

Cover

More Information
Summary:Treatment-resistant depression (TRD) is a chronic and severe psychiatric illness associated with limited therapeutic options. Deep brain stimulation (DBS) is a promising therapy for TRD patients. However, its safety and efficacy are still unclear. Here we reported the safety and efficacy of lateral habenula (LHb) DBS for a TRD patient who had failed medical, psychological, electroconvulsive, and ketamine therapy. The DBS system is compatible with 3T magnetic resonance imaging along with local field potential (LFP) streaming. Two DBS electrodes were implanted at the bilateral LHb without any complication. The patient showed acute stimulation effects and achieved long-term improvements in his depression, anxiety, and sleep with left LHb 160 Hz frequency stimulation, accompanying the change of LFPs. These results provided clinical evidence toward the safety and efficacy and electrophysiological basis of LHb DBS for TRD.
Bibliography:This article was submitted to Neuroimaging and Stimulation, a section of the journal Frontiers in Psychiatry
Edited by: André Schmidt, University of Basel, Switzerland
Reviewed by: Alexander Sartorius, University of Heidelberg, Germany; Natalia Gass, University of Heidelberg, Germany
These authors share first authorship
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2020.616501