Reversible jaundice in primary biliary cirrhosis due to hyperthyroidism

A patient with primary biliary cirrhosis had a dramatic deterioration in liver function with jaundice over 2 months as a result of development of Graves' disease. Clinical examination and radiological and cardiovascular investigations excluded heart failure and biliary obstruction as the cause...

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Published inGastroenterology (New York, N.Y. 1943) Vol. 106; no. 5; p. 1342
Main Authors Thompson, N P, Leader, S, Jamieson, C P, Burnham, W R, Burroughs, A K
Format Journal Article
LanguageEnglish
Published United States 01.05.1994
Subjects
Bilirubin - blood
Female
Humans
Hyperthyroidism - complications
Hyperthyroidism - physiopathology
Jaundice - blood
Jaundice - etiology
Liver - pathology
Liver - physiopathology
Liver Cirrhosis, Biliary - complications
Liver Cirrhosis, Biliary - pathology
Liver Cirrhosis, Biliary - physiopathology
Middle Aged
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Summary:A patient with primary biliary cirrhosis had a dramatic deterioration in liver function with jaundice over 2 months as a result of development of Graves' disease. Clinical examination and radiological and cardiovascular investigations excluded heart failure and biliary obstruction as the cause of this deterioration. The patient's jaundice entirely reversed with treatment of hyperthyroidism, with bilirubin levels decreasing from 244 to 16 mumol/L (14.35 to 0.94 mg/dL). Deterioration in liver function in a patient with primary biliary cirrhosis as a result of hyperthyroidism has not previously been described.
ISSN:0016-5085
DOI:10.1016/0016-5085(94)90028-0