Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering

• Published in: Journal of materials science. Materials in medicine Vol. 21; no. 7; pp. 2125 - 2132
• Main Authors: Hajiali, Hadi, Karbasi, Saeed, Hosseinalipour, Mohammad, Rezaie, Hamid Reza
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2010; Springer; Springer Nature B.V
• Subjects: 3-Hydroxybutyric Acid; Biodegradable materials; Biological and medical sciences; Biomaterials; Biomedical engineering; Biomedical Engineering and Bioengineering; Biomedical materials; Biotechnology; Bone and Bones - metabolism; Bones; Cell culture; Ceramics; Chemistry and Materials Science; Composites; Fundamental and applied biological sciences. Psychology; Glass; Health. Pharmaceutical industry; Industrial applications and implications. Economical aspects; Materials Science; Medical sciences; Miscellaneous; Nanocomposites; Nanocomposites - chemistry; Nanocomposites - ultrastructure; Nanoparticles; Nanoparticles - chemistry; Natural Materials; Polymer Sciences; Polymers - chemistry; Polymers - metabolism; Porosity; Regenerative Medicine/Tissue Engineering; Surfaces and Interfaces; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Thin Films; Tissue engineering; Tissue Engineering - methods; Bone Tissue Engineering; Bioactive Glass; Polyhydroxyalkanoates; Differential Thermal Analysis; Composite Scaffold; Tissue engineering; Nanoparticle; Ester polymer; Glass; Butyrate(hydroxy)polymer; Bioactive material; Scaffold; Composite material; Osteoarticular system; Aliphatic polymer; Preparation; Biomaterial; Nanocomposite; Bone; Biomedical engineering
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-010-4075-8

One of the most important challenges in composite scaffolds is pore architecture. In this study, poly (3-hydroxybutyrate) with 10% bioglass nanoparticles was prepared by the salt leaching processing technique, as a nanocomposite scaffold. The scaffolds were characterized by SEM, FTIR and DTA. The SEM images demonstrated uniformed porosities of appropriate sizes (about 250–300 μm) which are interconnected. Furthermore, higher magnification SEM images showed that the scaffold possesses less agglomeration and has rough surfaces that may improve cell attachment. In addition, the FTIR and DTA results showed favorable interaction between polymer and bioglass nanoparticles which improved interfaces in the samples. Moreover, the porosity of the scaffold was assessed, and the results demonstrated that the scaffold has uniform and high porosity in its structure (about 84%). Finally it can be concluded that this scaffold has acceptable porosity and morphologic character paving the way for further studies to be conducted from the perspective of bone tissue engineering.