miR-200b-3p in plasma is a potential diagnostic biomarker in oral squamous cell carcinoma

• Published in: Biomarkers Vol. 23; no. 2; pp. 137 - 141
• Main Authors: Sun, Guan, Cao, Ying, Wang, Peibei, Song, Hongmao, Bie, Tongwu, Li, Min, Huai, De
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.02.2018
• Subjects: Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - surgery; diagnosis; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miR-200b-3p; Mouth Neoplasms - diagnosis; Mouth Neoplasms - genetics; Mouth Neoplasms - surgery; Multivariate Analysis; oral squamous cell carcinoma; Prognosis; Treatment Outcome; Up-Regulation; diagnosis; miR-200b-3p; oral squamous cell carcinoma; prognosis
• ISSN: 1354-750X; 1366-5804
• DOI: 10.1080/1354750X.2017.1289241

Context: Circulating MicroRNAs (miRNAs) are emerging as novel biomarkers for tumour. Objective: Evaluate the diagnostic potential of plasma miR-200b-3p in oral squamous cell carcinoma (OSCC). Materials and methods: miR-200b-3p was detected by qRT-PCR in paired pre-operative and post-operative plasmas from 80 OSCC patients and 80 healthy controls. Results: Plasma miR-200b-3p was significantly upregulated in OSCC, and it was higher in WHO II/III grade than WHO I grade. The AUC of miR-200b-3p for OSCC was 0.9173. miR-200b-3p was significantly downregulated after surgery. High miR-200b-3p expression was associated with poor prognosis. Discussion and conclusion: Plasma miR-200b-3p could be a potential diagnostic biomarker for OSCC.