Maleness-on-the-Y ( MoY ) orchestrates male sex determination in major agricultural fruit fly pests

In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, ( ), encoding a small protein that is necessary and sufficien...

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Published inScience (American Association for the Advancement of Science) Vol. 365; no. 6460; pp. 1457 - 1460
Main Authors Meccariello, Angela, Salvemini, Marco, Primo, Pasquale, Hall, Brantley, Koskinioti, Panagiota, Dalíková, Martina, Gravina, Andrea, Gucciardino, Michela Anna, Forlenza, Federica, Gregoriou, Maria-Eleni, Ippolito, Domenica, Monti, Simona Maria, Petrella, Valeria, Perrotta, Maryanna Martina, Schmeing, Stephan, Ruggiero, Alessia, Scolari, Francesca, Giordano, Ennio, Tsoumani, Konstantina T, Marec, František, Windbichler, Nikolai, Arunkumar, Kallare P, Bourtzis, Kostas, Mathiopoulos, Kostas D, Ragoussis, Jiannis, Vitagliano, Luigi, Tu, Zhijian, Papathanos, Philippos Aris, Robinson, Mark D, Saccone, Giuseppe
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 27.09.2019
Subjects
Animals
Ceratitis capitata
Ceratitis capitata - genetics
Conserved Sequence
Embryo, Nonmammalian
Embryos
Female
Females
Fruit flies
Fruits
Genes, Insect
Genes, Y-Linked
Genetic control
Genetic crosses
Individualized Instruction
Insects
Male
Males
Masculinity
Pests
RNA Interference
Sex determination
Sex Determination Processes
Sex differentiation
Y Chromosome - genetics
Y chromosomes
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Summary:In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, ( ), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of in XY embryos causes feminization, whereas overexpression of in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.aax1318