A Case of Acute Disseminated Encephalomyelitis Associated with Hepatitis C Virus Infection

• Published in: Yonsei medical journal Vol. 53; no. 4; pp. 856 - 858
• Main Authors: Sim, Jae Eun, Lee, Jun-Bum, Cho, Yu Na, Suh, Sang Hyun, Kim, Ja Kyung, Lee, Kyung-Yul
• Format: Journal Article
• Language: English
• Published: Korea (South) Yonsei University College of Medicine 01.07.2012; 연세대학교의과대학
• Subjects: Case Report; Encephalomyelitis, Acute Disseminated - diagnosis; Encephalomyelitis, Acute Disseminated - drug therapy; Encephalomyelitis, Acute Disseminated - etiology; Encephalomyelitis, Acute Disseminated - virology; Female; Hepacivirus - pathogenicity; Hepatitis C - complications; Humans; Methylprednisolone - therapeutic use; Middle Aged; 의학일반
• ISSN: 0513-5796; 1976-2437; 1976-2437
• DOI: 10.3349/ymj.2012.53.4.856

Acute disseminated encephalomyelitis (ADEM) is a monophasic autoimmune demyelinating disease of the central nervous system, which typically follows acute viral or bacterial infection or vaccination. We report a case of ADEM associated with hepatitis C virus (HCV) infection with positive serum and cerebrospinal fluid (CSF) anti-HCV antibody. After steroid treatment, neurologic symptoms were improved. Virus triggers autoimmunity or direct viral invasion plays a part in the genesis of ADEM. This is the first reported case of ADEM with anti-HCV antibody in the CSF.