DisSIRTing on LXR and Cholesterol Metabolism

The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent...

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Bibliographic Details
Published inCell metabolism Vol. 6; no. 5; pp. 343 - 345
Main Authors Feige, Jerome N., Auwerx, Johan
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2007
Elsevier
Subjects
Animals
Biochemistry, Molecular Biology
Biological Transport
Cholesterol - metabolism
Humans
Life Sciences
Lipid Metabolism
Models, Biological
Molecular biology
Receptors, Cytoplasmic and Nuclear - metabolism
Sirtuins - metabolism
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Summary:The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2007.10.003