Chromosome mapping of RNF16 and Rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family

• Published in: Cytogenetic and genome research Vol. 89; no. 1-2; pp. 56 - 58
• Main Authors: OGAWA, S, SAITO, T, INOUE, S, MATSUDA, Y, SEKI, N, HAYASHI, A, ORIMO, A, HOSOI, T, OUCHI, Y, MURAMATSU, M, HORI, T
• Format: Journal Article
• Language: English
• Published: Freiburg Karger 01.01.2000; Basel S. Karger AG; Paris
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Carrier Proteins - chemistry; Carrier Proteins - genetics; chromosome 10; chromosome 11; Chromosome Banding; Chromosomes, Human, Pair 1 - genetics; Conserved Sequence - genetics; Fundamental and applied biological sciences. Psychology; Genes. Genome; Humans; Hybrid Cells; In Situ Hybridization, Fluorescence; Mice; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Multigene Family - genetics; Physical Chromosome Mapping; Rats; RING finger proteins; Rnf16 gene; RNF16 protein; Sequence Alignment; terf protein; Ubiquitin-Protein Ligases; Genetic mapping; Human; Rat; Nucleotide sequence; Rodentia; Chromosome A1; Homology; Gene expression; Testicle; Vertebrata; Mammalia; Gene; Mouse; Chromosome 10; Fluorescence in situ hybridization; Chromosome 11; Physical map
• ISSN: 0301-0171; 1424-8581; 1424-859X
• DOI: 10.1159/000015564

RNF16 (ring finger protein 16; alias terf), a member of the RING finger family, has been shown to be exclusively expressed in the testis. Human RNF16 is located at 1q42 based on PCR-assisted analysis of both a human/rodent mono-chromosomal hybrid cell panel and a radiation hybrid-mapping panel. On the other hand, chromosomal mapping of the RNF16 gene by fluorescence in situ hybridization reveals that mouse Rnf16 is located at 11B1.2-B1.3 and rat Rnf16 at 10q22. These results provide additional evidence that the mouse 11B region displays conserved linkage homology with the rat 10q22 region, whereas in the case of RNF16, this homology is only conserved among rodents, distinct from the 1q42 region of the human genome.