Human Papillomavirus Prevalence and Genotype Distribution among HIV-Infected Women in Korea

• Published in: Journal of Korean medical science Vol. 29; no. 1; pp. 32 - 37
• Main Authors: Park, Eun Kyoung, Cho, Heerim, Lee, Sun Hee, Lee, Seung Geun, Lee, Sang Yeup, Kim, Ki Hyung, Lee, Chang Hun, Chung, Joo Seop, Kwak, Ihm Soo
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.01.2014; 대한의학회
• Subjects: Adult; Age Factors; Cervix Uteri - virology; DNA Probes, HPV; DNA, Viral - genetics; Female; Genotype; HIV Infections - complications; HIV Infections - epidemiology; HIV Infections - genetics; HIV-1 - genetics; Human papillomavirus 11 - genetics; Human papillomavirus 11 - isolation & purification; Human papillomavirus 16 - genetics; Human papillomavirus 16 - isolation & purification; Human papillomavirus 18 - genetics; Human papillomavirus 18 - isolation & purification; Human papillomavirus 6 - genetics; Human papillomavirus 6 - isolation & purification; Humans; Middle Aged; Original; Papillomavirus Infections - complications; Papillomavirus Infections - epidemiology; Papillomavirus Infections - genetics; Prevalence; Republic of Korea - epidemiology; Retrospective Studies; Risk Factors; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - virology; 의학일반; Republic of Korea; Women; Genotype; Prevalence; Human Papillomavirus; HIV
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2014.29.1.32

The epidemiology on human papillomavirus (HPV) among human immunodeficiency virus (HIV)-infected women in Korea is not well established. A retrospective study was conducted to determine the prevalence and genotype distribution of HPV infection among HIV-infected women in Korea. HPV DNA genotype and cervical cytology were examined in 60 HIV-positive women and 1,938 HIV-negative women. HPV genotypes were analyzed by using a HPV DNA chip. HIV-infected women had higher prevalence of high-risk HPV (hr-HPV) infection (30% vs 4.9%, adjusted odds ratio [AOR], 6.96; 95% confidence interval [CI], 3.63-13.34, P<0.001) and abnormal cervical cytology (18.3% vs 1.8%, AOR, 10.94; 95% CI, 5.18-23.1, P<0.001) compared with controls. The most common hr-HPV genotype detected in HIV-infected women was HPV 16 (10%), followed by 18 (6.7%) and 52 (5%). Prevalence of quadrivalent vaccine-preventable types (HPV 6, 11, 16, and 18) was 21.7% and 2.3% in HIV-positive women and HIV-negative women, respectively. Age was a significant risk factor for hr-HPV infection in HIV-infected women (P=0.039). The presence of hr-HPV was significantly associated with abnormal cervical cytology (P<0.001). These findings suggest that HPV testing for cervical cancer screening in HIV-infected women would be necessary, particularly among young age group.