Investigation of parent-of-origin effects in ADHD candidate genes
Attention deficit hyperactivity disorder (ADHD) is a common early‐onset childhood disorder with a strong genetic component. Results from previous studies have suggested that there may be a parent‐of‐origin effect for ADHD candidate genes. In particular, a recent investigation identified a pattern of...
Saved in:
Published in | American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 144B; no. 6; pp. 776 - 780 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
05.09.2007
Wiley-Liss |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Attention deficit hyperactivity disorder (ADHD) is a common early‐onset childhood disorder with a strong genetic component. Results from previous studies have suggested that there may be a parent‐of‐origin effect for ADHD candidate genes. In particular, a recent investigation identified a pattern of paternal over‐transmission of risk alleles for nine ADHD candidate genes. We examined this phenomenon in a sample of 291 trios for five genes previously associated with ADHD (HTR1B, SNAP‐25, DRD5, DAT1, and BDNF). Using a dense map of markers and two analytic methods in this relatively large family‐based sample, we do not find any evidence for significant paternal over‐transmission of risk alleles in these candidate loci. Thus, we conclude that a substantial parent‐of‐origin effect is unlikely for these leading ADHD candidate genes. © 2007 Wiley‐Liss, Inc. |
---|---|
Bibliography: | How to cite this article: Kim JW, Waldman ID, Faraone SV, Biederman J, Doyle AE, Purcell S, Arbeitman L, Fagerness J, Sklar P, Smoller JW. 2007. Investigation of Parent-of-Origin Effects in ADHD Candidate Genes. Am J Med Genet Part B 144B:776-780. istex:8247C486DD6BE48C932E235AF60D646E5AC25432 ark:/67375/WNG-VCXJ67Q0-J NIH - No. HD37694; No. HD37999; No. MH66877 ArticleID:AJMG30519 How to cite this article: Kim JW, Waldman ID, Faraone SV, Biederman J, Doyle AE, Purcell S, Arbeitman L, Fagerness J, Sklar P, Smoller JW. 2007. Investigation of Parent‐of‐Origin Effects in ADHD Candidate Genes. Am J Med Genet Part B 144B:776–780. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1552-4841 1552-485X |
DOI: | 10.1002/ajmg.b.30519 |