Investigation of parent-of-origin effects in ADHD candidate genes

Attention deficit hyperactivity disorder (ADHD) is a common early‐onset childhood disorder with a strong genetic component. Results from previous studies have suggested that there may be a parent‐of‐origin effect for ADHD candidate genes. In particular, a recent investigation identified a pattern of...

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Published inAmerican journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 144B; no. 6; pp. 776 - 780
Main Authors Kim, Jang Woo, Waldman, Irwin D., Faraone, Stephen V., Biederman, Joseph, Doyle, Alysa E., Purcell, Shaun, Arbeitman, Lori, Fagerness, Jesen, Sklar, Pamela, Smoller, Jordan W.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.09.2007
Wiley-Liss
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Summary:Attention deficit hyperactivity disorder (ADHD) is a common early‐onset childhood disorder with a strong genetic component. Results from previous studies have suggested that there may be a parent‐of‐origin effect for ADHD candidate genes. In particular, a recent investigation identified a pattern of paternal over‐transmission of risk alleles for nine ADHD candidate genes. We examined this phenomenon in a sample of 291 trios for five genes previously associated with ADHD (HTR1B, SNAP‐25, DRD5, DAT1, and BDNF). Using a dense map of markers and two analytic methods in this relatively large family‐based sample, we do not find any evidence for significant paternal over‐transmission of risk alleles in these candidate loci. Thus, we conclude that a substantial parent‐of‐origin effect is unlikely for these leading ADHD candidate genes. © 2007 Wiley‐Liss, Inc.
Bibliography:How to cite this article: Kim JW, Waldman ID, Faraone SV, Biederman J, Doyle AE, Purcell S, Arbeitman L, Fagerness J, Sklar P, Smoller JW. 2007. Investigation of Parent-of-Origin Effects in ADHD Candidate Genes. Am J Med Genet Part B 144B:776-780.
istex:8247C486DD6BE48C932E235AF60D646E5AC25432
ark:/67375/WNG-VCXJ67Q0-J
NIH - No. HD37694; No. HD37999; No. MH66877
ArticleID:AJMG30519
How to cite this article: Kim JW, Waldman ID, Faraone SV, Biederman J, Doyle AE, Purcell S, Arbeitman L, Fagerness J, Sklar P, Smoller JW. 2007. Investigation of Parent‐of‐Origin Effects in ADHD Candidate Genes. Am J Med Genet Part B 144B:776–780.
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30519