Socioeconomic status and risk of hospitalization among individuals with cystic fibrosis in Ontario, Canada

• Published in: Pediatric pulmonology Vol. 46; no. 4; pp. 376 - 384
• Main Authors: Stephenson, Anne, Hux, Janet, Tullis, Elizabeth, Austin, Peter C., Corey, Mary, Ray, Joel
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2011; Wiley-Liss
• Subjects: Adolescent; Adult; Biological and medical sciences; Child; cystic fibrosis; Cystic Fibrosis - epidemiology; Cystic Fibrosis - physiopathology; Errors of metabolism; Female; General aspects; Hospitalization; Humans; income; Longitudinal Studies; Male; Medical sciences; Metabolic diseases; Miscellaneous hereditary metabolic disorders; Ontario - epidemiology; Pneumology; Risk; Severity of Illness Index; Social Class; socioeconomic status; Treatment Outcome; Young Adult; Canada; North America; Ontario; America; Human; income; Pediatrics; Socioeconomic status; Respiratory disease; Metabolic diseases; Cystic fibrosis; Risk; Hospitalization; Epidemiology; Genetic disease; Risk factor; Digestive diseases; Pancreatic disease; Pneumology
• ISSN: 8755-6863; 1099-0496; 1099-0496
• DOI: 10.1002/ppul.21368

Background Socioeconomic status (SES) is a strong predictor of outcomes in cystic fibrosis (CF); however, there are no published studies evaluating this relationship in Canadians with CF. The objective of this study was to assess the effect of SES on annual hospitalization rates in a large cohort of pediatric and adult CF subjects under a universal health care system. Methods A population‐based longitudinal study was completed in Ontario from 1993 to 2002 using a comprehensive CF registry containing patient‐level data, linked to provincial health care administrative databases. Income quintiles were derived at the neighborhood level using postal code information and Statistics Canada census data. The effect of income quintile on the annual hospitalization rate for respiratory‐related illness was estimated by Poisson regression using generalized estimating equations, and was expressed as a rate ratio (RR) and 95% confidence interval (CI). The analysis was adjusted for age, sex, lung function, nutritional status, the presence of diabetes, area of residence, and distance between the subject's residence and the reporting CF centre. Results A total of 1,174 participants over the age of 6 years contributed 8,444 patient‐years of data. No statistically significant differences in annual hospitalization rates for respiratory‐related causes were found between the lowest and highest income quintiles (adjusted RR 1.17 [95% CI 0.96–1.43]). The effect of income quintile remained non‐significant across a majority of markers of CF disease severity and across a range of subgroups. Conclusions After adjusting for important covariates, no SES‐disparities in hospitalization rates were found in a large Canadian pediatric and adult CF cohort. It may be the distinctive combination of universal health care, a national network of specialty CF clinics, and drug and travel coverage available in Ontario that results in similar hospitalization rates regardless of SES. Pediatr Pulmonol. 2011; 46:376–384. © 2010 Wiley‐Liss, Inc.