Anti-inflammatory effects of mao-bushi-saishin-to in mice and rats

Effects of Mao-Bushi-Saishin-to (MBS) on anti-inflammatory activities were examined in mice and rats. MBS significantly inhibited the increase in vascular permeability induced by acetic acid, the ear edema induced by arachidonic acid and phorbol ester, and the cutaneous extravasation induced by brad...

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Published inThe American journal of Chinese medicine (1979) Vol. 26; no. 2; p. 171
Main Authors Ikeda, Y, Iijima, O T, Iizuka, A, Ishige, A, Amagaya, S, Komatsu, Y, Okada, M, Abe, C, Fujihira, E
Format Journal Article
LanguageEnglish
Published Singapore 1998
Subjects
Acetic Acid
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Arachidonic Acid
Capillary Permeability - drug effects
Carrageenan
Drugs, Chinese Herbal - pharmacology
Edema - chemically induced
Edema - drug therapy
Male
Mice
Mice, Inbred ICR
Phorbol Esters
Plant Extracts
Rats
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Summary:Effects of Mao-Bushi-Saishin-to (MBS) on anti-inflammatory activities were examined in mice and rats. MBS significantly inhibited the increase in vascular permeability induced by acetic acid, the ear edema induced by arachidonic acid and phorbol ester, and the cutaneous extravasation induced by bradykinin and histamine. MBS, however, was not effective against the serotonin-induced cutaneous permeability increase in mice. MBS significantly inhibited carrageenin-induced hind foot edema and cotton pellet-induced granulation tissue growth in rats. These results show that MBS may exert anti-inflammatory effects through the underlying mechanism(s) of preventing mediator release from mast cells and macrophages.
ISSN:0192-415X
1793-6853
DOI:10.1142/s0192415x98000221