Treatment of primary monosymptomatic nocturnal enuresis with desmopressin: predictive factors

• Published in: BJU international Vol. 88; no. 6; pp. 572 - 576
• Main Authors: Kruse, S., Hellström, A.L., Hanson, E., Hjälmås, K., Sillén, U.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2001; Blackwell
• Subjects: Biological and medical sciences; Child; Deamino Arginine Vasopressin; Deamino Arginine Vasopressin - therapeutic use; desmopressin; drug therapy; Enuresis; Enuresis - drug therapy; Enuresis - genetics; Farmaceutisk vetenskap; Female; Genetic Diseases; Genetic Diseases, Inborn - drug therapy; genetics; Humans; Inborn; Male; Medical sciences; Other Social Sciences not elsewhere specified; Pharmaceutical Sciences; Pharmacology. Drug treatments; predictive factors; Predictive Value of Tests; Renal Agents; Renal Agents - therapeutic use; therapeutic use; Treatment Outcome; Urinary system; Övrig annan samhällsvetenskap; Human; Desmopressin; Urinary system disease; Enuresis; Prediction; Result; Urinary incontinence; Voiding dysfunction; Symptomatology; Chemotherapy; Treatment; Primary; Child; Nocturia
• ISSN: 1464-4096; 1464-410X
• DOI: 10.1046/j.1464-410X.2001.02321.x

Objective To investigate predictive factors for the outcome of treatment of primary monosymptomatic nocturnal enuresis (PMNE) with desmopressin. Patients and methods Data from a large open multicentre study were analysed. The study comprised 399 children with PMNE who were recruited for long‐term desmopressin treatment. Before treatment a history was taken and the children observed for 4 weeks. After a 6‐week dose‐titration period with desmopressin, the children were classified into four groups depending on the response rate. Results The children who improved during desmopressin treatment were older, had fewer wet nights during the observation period and had only one wet episode during the night, mostly after midnight. Many of them did not require the maximum dose of desmopressin to become dry. No hereditary factor for the response to desmopressin was found. Conclusion Those most likely to be permanently dry with desmopressin treatment are older children who respond to 20 µg desmopressin and who do not wet frequently.