Diffusion-weighted MRI of the lung with hyperpolarized helium-3: A study of reproducibility
Purpose To determine the reproducibility of several parameters of the ADC measurement by calculating the scan‐to‐scan intrasubject variability. Materials and Methods Measurements were performed using a gradient‐echo sequence with a bipolar gradient for diffusion weighting (b = 3.89 sec/cm2). Five pa...
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Published in | Journal of magnetic resonance imaging Vol. 21; no. 6; pp. 765 - 774 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
01.06.2005
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Subjects | |
Online Access | Get full text |
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Summary: | Purpose
To determine the reproducibility of several parameters of the ADC measurement by calculating the scan‐to‐scan intrasubject variability.
Materials and Methods
Measurements were performed using a gradient‐echo sequence with a bipolar gradient for diffusion weighting (b = 3.89 sec/cm2). Five patients with pulmonary emphysema, and six healthy‐lung volunteers were included in the study. Images were acquired after inspiration of 3He during a single inspiratory breath‐hold. To assess the reproducibility, the measurement was performed twice (time between measurements = 20 minutes) without repositioning the subjects. Analysis was performed on the basis of region‐of‐interest (ROI) analysis and global lung ADC histograms.
Results
The mean ADC of a ROI varied by 5.1% between two measurements for volunteers and by 6.1% for patients. In the global evaluation, the 75th percentile demonstrated the best reproducibility (2%), while other parameters showed variations up to 12%. Only the variation of the standard deviation (SD) and the measure of homogeneity of the ADC map showed a significant difference between patients and volunteers.
Conclusion
Diffusion‐weighted imaging (DWI) is a well‐reproducible method for assessing the lung microstructure. J. Magn. Reson. Imaging 2005;21:765–774. © 2005 Wiley‐Liss, Inc. |
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Bibliography: | ark:/67375/WNG-T1QZ3BHN-5 ArticleID:JMRI20300 European Commission German Research Council - No. FOR 474 istex:F675081474A73729F09C89F944AC94B79F2A8B1C ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1053-1807 1522-2586 |
DOI: | 10.1002/jmri.20300 |