Reducing the inhibitory effect of cigarette smoke on the activity of oral peroxidase by the addition of berberine in cigarette filter

This study was carried out to evaluate the effect of cigarette smoke (CS) on the activity of oral peroxidase (OPO) after berberine was added to the cigarette filter. Activated carbon fiber (ACF) was chosen to load berberine as a part of the cellulose acetate (CA) filter to obtain the modified B-ACF...

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Bibliographic Details
Published inToxicology and Industrial Health Vol. 29; no. 4; pp. 317 - 324
Main Authors Wu, Jinfeng, Ye, Xiaoli, Cui, Xuelong, Li, Xuegang, Zheng, Lifeng, Chen, Zhu
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.05.2013
Sage Publications Ltd
Subjects
Activated carbon
Antioxidants
Berberine - pharmacology
Carbon fibers
Cellulose acetate
Cigarettes
Health
Humans
Hydrogen cyanide
Inhibition
Nicotiana - chemistry
Nicotine
Oral cancer
Peroxidase
Peroxidase - antagonists & inhibitors
Peroxidase - metabolism
Pharmaceutical sciences
Saliva - drug effects
Saliva - enzymology
Smoke
Smoke - analysis
Smoking
Smoking - metabolism
Tobacco
Tobacco Products
Toxicology
China
Oral peroxidase activity
filter
saliva
cigarette smoke
hydrogen cyanide
berberine
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Summary:This study was carried out to evaluate the effect of cigarette smoke (CS) on the activity of oral peroxidase (OPO) after berberine was added to the cigarette filter. Activated carbon fiber (ACF) was chosen to load berberine as a part of the cellulose acetate (CA) filter to obtain the modified B-ACF cigarette filter. Then the effects of CS from the testing cigarettes on the activity of OPO were investigated in vitro by the 2-nitrobenzoic acid assay, and the smoke chemistry was also analyzed, especially the content of hydrogen cyanide (HCN) in the CS. The results indicated that the loss of activity of OPO in B-ACF filter cigarette group decreased by 20% and 25%, compared with those of ACF and CA filter cigarette groups, respectively. The relative residual activity of OPO in B-ACF filter group was increased with the increase of berberine in the filter compared with the CA filter group. It could be observed that the reduction in HCN might be related to the berberine in the cigarette filter, reducing the inhibition of CS on the activity of OPO.
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ISSN:0748-2337
1477-0393
DOI:10.1177/0748233711433933